激素替代療法不能完全防止骨質(zhì)疏松
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2001年1月15日
路透社紐約健康消息 激素代替療法過去一直被認(rèn)為有助于防止絕經(jīng)期后由于衰老所致的骨質(zhì)疏松，然而一項(xiàng)新的研究卻發(fā)現(xiàn)仍有部份參與該治療的女性繼續(xù)發(fā)生骨質(zhì)疏松。
以洛杉磯加利福尼亞大學(xué)博士吉爾·格里恩代爾為首的研究小組對(duì)670名婦女進(jìn)行了研究，其中538位正在接受激素替代療法，另外132位則并未使用任何激素。結(jié)果發(fā)現(xiàn)，在接受激素替代療法的第一年，約5%的婦女下部脊骨骨質(zhì)至少丟失1%；15%的婦女臀部骨質(zhì)至少丟失1%；療程的第二至第三年，8%的婦女出現(xiàn)脊骨骨質(zhì)丟失；12%的婦女出現(xiàn)髖骨骨質(zhì)丟失。此外，沒有用激素的女性有60%發(fā)生了骨質(zhì)丟失。
研究小組認(rèn)為：在接受激素替代療法的婦女中發(fā)生骨質(zhì)損失的比例很少，估計(jì)其中10%至30%是接受了非正規(guī)性治療，這并不意味著對(duì)這些女性的治療失敗。如果沒有接受激素替代療法，她們骨損失的程度可能會(huì)更嚴(yán)重。當(dāng)進(jìn)行激素替代療法時(shí)，高齡是導(dǎo)致骨質(zhì)掉失的最重要的危險(xiǎn)因素，相對(duì)年輕的女人較少發(fā)生骨損失。
, 百拇醫(yī)藥
研究小組還指出，骨損失可分為兩種類型：即骨損失發(fā)生在激素治療的第一年或第二至第三年，很少女性骨損失同時(shí)發(fā)生在這兩個(gè)時(shí)期；女性在激素替代治療的第一年出現(xiàn)骨質(zhì)增加或減少并不意味著這種情況今后仍會(huì)持續(xù)。某些女性在治療的第一年出現(xiàn)骨損失，而另外一些婦女骨損失則發(fā)生在激素治療的第二或第三年。
Some Women Lose Bone While Taking Hormones
NEW YORK (Reuters Health) - Hormone replacement therapy is thought to help prevent bone loss due to aging when taken after menopause. However, new study findings show that at least some women continue to lose bone when taking hormones.
, 百拇醫(yī)藥
About 5% of women on hormone therapy lost at least 1% of bone mass in the lower spine within the first year of treatment, and 15% of women lost at least 1% of hip bone mass. During the second and third years, 8% of women lost spinal bone mass, while 12% lost hip bone mass.
The study included 538 women taking hormones and 132 women who were not taking any hormones, according to the report in the November 13th issue of the journal Archives of Internal Medicine.
, 百拇醫(yī)藥
But such bone loss is rare and does not necessarily mean that the treatment has failed in these women. It is possible that they would have lost even more bone mass if they had not started taking hormones, according to the team of researchers led by Dr. Gail A. Greendale, of the University of California, Los Angeles.
It has been thought that some women lose bone mass while taking hormone replacement, but the estimates, ranging from 10% to 30% of women, have been informal, according to the researchers.
, 百拇醫(yī)藥
Overall, older age was the most important risk factor for losing bone while on hormone replacement therapy. The researchers report that there appeared to be two groups of women who lost bone mass--those who lost bone mass during the first year and those who lost during the second and third years. Few women lost bone during both periods.
Not surprisingly, many of the women not taking hormone therapy lost bone, but about 40% of these women did not lose any bone mass during the study, the authors point out.
, 百拇醫(yī)藥
The study has several important implications, according to Greendale and her colleagues. They note that bone loss is rare in relatively young women who take hormone therapy after menopause.
The team also points out that whether a woman gains or loses bone mass during the first year of taking hormone replacement therapy is not a good indication of whether she will continue to gain or lose bone. Some women stop losing bone after the first year of treatment while others begin losing bone in the second or third year, they note.
SOURCE: Archives of Internal Medicine 2000;160:3065-3071.
載自家庭醫(yī)生醫(yī)療保健網(wǎng), 百拇醫(yī)藥
以洛杉磯加利福尼亞大學(xué)博士吉爾·格里恩代爾為首的研究小組對(duì)670名婦女進(jìn)行了研究，其中538位正在接受激素替代療法，另外132位則并未使用任何激素。結(jié)果發(fā)現(xiàn)，在接受激素替代療法的第一年，約5%的婦女下部脊骨骨質(zhì)至少丟失1%；15%的婦女臀部骨質(zhì)至少丟失1%；療程的第二至第三年，8%的婦女出現(xiàn)脊骨骨質(zhì)丟失；12%的婦女出現(xiàn)髖骨骨質(zhì)丟失。此外，沒有用激素的女性有60%發(fā)生了骨質(zhì)丟失。
研究小組認(rèn)為：在接受激素替代療法的婦女中發(fā)生骨質(zhì)損失的比例很少，估計(jì)其中10%至30%是接受了非正規(guī)性治療，這并不意味著對(duì)這些女性的治療失敗。如果沒有接受激素替代療法，她們骨損失的程度可能會(huì)更嚴(yán)重。當(dāng)進(jìn)行激素替代療法時(shí)，高齡是導(dǎo)致骨質(zhì)掉失的最重要的危險(xiǎn)因素，相對(duì)年輕的女人較少發(fā)生骨損失。
, 百拇醫(yī)藥
研究小組還指出，骨損失可分為兩種類型：即骨損失發(fā)生在激素治療的第一年或第二至第三年，很少女性骨損失同時(shí)發(fā)生在這兩個(gè)時(shí)期；女性在激素替代治療的第一年出現(xiàn)骨質(zhì)增加或減少并不意味著這種情況今后仍會(huì)持續(xù)。某些女性在治療的第一年出現(xiàn)骨損失，而另外一些婦女骨損失則發(fā)生在激素治療的第二或第三年。
Some Women Lose Bone While Taking Hormones
NEW YORK (Reuters Health) - Hormone replacement therapy is thought to help prevent bone loss due to aging when taken after menopause. However, new study findings show that at least some women continue to lose bone when taking hormones.
, 百拇醫(yī)藥
About 5% of women on hormone therapy lost at least 1% of bone mass in the lower spine within the first year of treatment, and 15% of women lost at least 1% of hip bone mass. During the second and third years, 8% of women lost spinal bone mass, while 12% lost hip bone mass.
The study included 538 women taking hormones and 132 women who were not taking any hormones, according to the report in the November 13th issue of the journal Archives of Internal Medicine.
, 百拇醫(yī)藥
But such bone loss is rare and does not necessarily mean that the treatment has failed in these women. It is possible that they would have lost even more bone mass if they had not started taking hormones, according to the team of researchers led by Dr. Gail A. Greendale, of the University of California, Los Angeles.
It has been thought that some women lose bone mass while taking hormone replacement, but the estimates, ranging from 10% to 30% of women, have been informal, according to the researchers.
, 百拇醫(yī)藥
Overall, older age was the most important risk factor for losing bone while on hormone replacement therapy. The researchers report that there appeared to be two groups of women who lost bone mass--those who lost bone mass during the first year and those who lost during the second and third years. Few women lost bone during both periods.
Not surprisingly, many of the women not taking hormone therapy lost bone, but about 40% of these women did not lose any bone mass during the study, the authors point out.
, 百拇醫(yī)藥
The study has several important implications, according to Greendale and her colleagues. They note that bone loss is rare in relatively young women who take hormone therapy after menopause.
The team also points out that whether a woman gains or loses bone mass during the first year of taking hormone replacement therapy is not a good indication of whether she will continue to gain or lose bone. Some women stop losing bone after the first year of treatment while others begin losing bone in the second or third year, they note.
SOURCE: Archives of Internal Medicine 2000;160:3065-3071.
載自家庭醫(yī)生醫(yī)療保健網(wǎng), 百拇醫(yī)藥
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