并非生而平等
在細(xì)胞的不對等分裂中，前體細(xì)胞被極性的分配到一個子細(xì)胞中去。有絲分裂紡垂體會在胞質(zhì)分裂之前沿著正確的軸定向。在果蠅的中樞神經(jīng)系統(tǒng)，神經(jīng)母細(xì)胞沿著頂部－基部軸不對等的分裂。Petronczki and Knoblich, and Wodarz et al.發(fā)現(xiàn)這個過程類似于線蟲中第一次細(xì)胞分裂。在神經(jīng)母細(xì)胞中，PDZ頂端蛋白Bazooka與DmPAR-6形成復(fù)合物，這個復(fù)合物調(diào)控頂基極性。對于細(xì)胞命運決定子的正確基部定位和細(xì)胞不對等分裂是必需的。
Ohshiro et al. and Peng et al.發(fā)現(xiàn)抑癌基因lgl和dlg對神經(jīng)母細(xì)胞基皮層上的細(xì)胞命運決定子定位是必需的，與Bazooka
complex相獨立。紡錘體的定位已知是與Bazooka complex頂端蛋白Inscuteable和Pins有關(guān)的。
在果蠅周圍神經(jīng)系統(tǒng)中，一系列的不對等分裂導(dǎo)致形成一個外部感覺器官從一個前體細(xì)胞中產(chǎn)生出來。Roegiers
et al. and Bellaïche et al.發(fā)現(xiàn)當(dāng)前體細(xì)胞pI cell分裂的時候，Numb和PON在紡錘體轉(zhuǎn)向沿著前后軸之前定位在細(xì)胞的前極部。Numb的定位和紡錘體的正確定向依賴于frizzled和flamingo兩個與極性有關(guān)的基因。
Roegiers
et al.也發(fā)現(xiàn)，pIIb cell
的分裂與神經(jīng)母細(xì)胞的分裂是相似的，他們認(rèn)為這個差別是因為pIIb Cell表達(dá)Inscuteable引起的，他們的研究成果讓我們認(rèn)識到，調(diào)控細(xì)胞的不對等分裂過程在這幾種模式生物中可能是相當(dāng)類似的。
相關(guān)文章：
ORIGINAL RESEARCH PAPERS
Petronczki, M. & Knoblich,J. A. DmPAR-6 directs epithelial polarity and asymmetric cell division
of neuroblasts in Drosophila. Nature Cell Biol. 3, 43–49 ( 2001)
[Contents page]
Bellaïche, Y. et al.
Frizzled regulates the localization of cell-fate determinants and
mitotic spindle rotation during asymmetric cell division. Nature Cell
Biol. 3, 50–57 (2001) [Contents page]
Roegiers, F. et al. Two types
of asymmetric divisions in the Drosophila sensory organ precursor cell
lineage. Nature Cell Biol. 3, 58–67 (2001) [Contents page]
Ohshiro, T. et al. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408 , 593–596 (2000) PubMed
Peng, C.-Y. et al. The tumour-suppressor
genes lgl and dlg regulate basal protein targeting in Drosophila
neuroblasts. Nature 408, 596–600 ( 2000) PubMed
Wodarz, A. et al. Drosophila
atypical protein kinase C associates with Bazooka and controls
polarity of epithelia and neuroblasts. J. Cell Biol. 150, 1361–1374 ( 2000) PubMed, 百拇醫(yī)藥
Ohshiro et al. and Peng et al.發(fā)現(xiàn)抑癌基因lgl和dlg對神經(jīng)母細(xì)胞基皮層上的細(xì)胞命運決定子定位是必需的，與Bazooka
complex相獨立。紡錘體的定位已知是與Bazooka complex頂端蛋白Inscuteable和Pins有關(guān)的。
在果蠅周圍神經(jīng)系統(tǒng)中，一系列的不對等分裂導(dǎo)致形成一個外部感覺器官從一個前體細(xì)胞中產(chǎn)生出來。Roegiers
et al. and Bellaïche et al.發(fā)現(xiàn)當(dāng)前體細(xì)胞pI cell分裂的時候，Numb和PON在紡錘體轉(zhuǎn)向沿著前后軸之前定位在細(xì)胞的前極部。Numb的定位和紡錘體的正確定向依賴于frizzled和flamingo兩個與極性有關(guān)的基因。
Roegiers
et al.也發(fā)現(xiàn)，pIIb cell
的分裂與神經(jīng)母細(xì)胞的分裂是相似的，他們認(rèn)為這個差別是因為pIIb Cell表達(dá)Inscuteable引起的，他們的研究成果讓我們認(rèn)識到，調(diào)控細(xì)胞的不對等分裂過程在這幾種模式生物中可能是相當(dāng)類似的。
相關(guān)文章：
ORIGINAL RESEARCH PAPERS
Petronczki, M. & Knoblich,J. A. DmPAR-6 directs epithelial polarity and asymmetric cell division
of neuroblasts in Drosophila. Nature Cell Biol. 3, 43–49 ( 2001)
[Contents page]
Bellaïche, Y. et al.
Frizzled regulates the localization of cell-fate determinants and
mitotic spindle rotation during asymmetric cell division. Nature Cell
Biol. 3, 50–57 (2001) [Contents page]
Roegiers, F. et al. Two types
of asymmetric divisions in the Drosophila sensory organ precursor cell
lineage. Nature Cell Biol. 3, 58–67 (2001) [Contents page]
Ohshiro, T. et al. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408 , 593–596 (2000) PubMed
Peng, C.-Y. et al. The tumour-suppressor
genes lgl and dlg regulate basal protein targeting in Drosophila
neuroblasts. Nature 408, 596–600 ( 2000) PubMed
Wodarz, A. et al. Drosophila
atypical protein kinase C associates with Bazooka and controls
polarity of epithelia and neuroblasts. J. Cell Biol. 150, 1361–1374 ( 2000) PubMed, 百拇醫(yī)藥
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