生物節(jié)律調(diào)節(jié)在染色體水平的反映
Sassone-Corsi and colleagues研究了在上書反應(yīng)中組蛋白H3磷酸化的變化,這是在染色質(zhì)重構(gòu)反應(yīng)中的核心事件。他們觀察到了,在小鼠SCN中有光誘導(dǎo)的磷酸化,但在視網(wǎng)膜和松果體中就沒(méi)有。研究者接著發(fā)現(xiàn),H3的磷酸化的時(shí)程與一個(gè)極早期反應(yīng)基因c-fos在SCN神經(jīng)元中誘導(dǎo)模式是相吻合的,這提示了兩者的關(guān)聯(lián)性。如果對(duì)小鼠給藥baclofen,一個(gè)能阻斷節(jié)律移動(dòng)的藥物,H3的磷酸化和c-fos的表達(dá)都被抑制了,這更說(shuō)明了在它們之間可能有共同的信號(hào)途徑。這個(gè)結(jié)果向我們揭示了節(jié)律變化在染色體水平上調(diào)控的可能機(jī)制。
相關(guān)文章:
ORIGINAL RESEARCH PAPER
Crosio, C., Vermakian, N., Allis, C. D. & Sassone-Corsi, P. Light induces chromatin modification in cells of the mammalian circadian clock. Nature Neurosci. 3, 1241–1247 (2000)[Contents page] PubMed
FURTHER READING
Cheung, P., Allis, C. D. & Sassone-Corsi, P. Signaling to chromatin through histone modifications Cell 103, 263–271 (2000) PubMed, http://www.www.srpcoatings.com
相關(guān)文章:
ORIGINAL RESEARCH PAPER
Crosio, C., Vermakian, N., Allis, C. D. & Sassone-Corsi, P. Light induces chromatin modification in cells of the mammalian circadian clock. Nature Neurosci. 3, 1241–1247 (2000)[Contents page] PubMed
FURTHER READING
Cheung, P., Allis, C. D. & Sassone-Corsi, P. Signaling to chromatin through histone modifications Cell 103, 263–271 (2000) PubMed, http://www.www.srpcoatings.com
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