檞皮素對大鼠酒精性脂肪肝核轉(zhuǎn)錄因子表達的影響
酒精性脂肪肝;檞皮素;腫瘤壞死因子-α;核轉(zhuǎn)錄因子;大鼠,張禁,譚詩云,朱衛(wèi)芳,蔣琳,程景輝,通訊作者:,EffectsofquercetinontheexpressionofnuclearfactorkappaBinalcoholicfattyl
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張禁, 譚詩云, 朱衛(wèi)芳, 武漢大學(xué)人民醫(yī)院消化內(nèi)科 湖北省武漢市 430060
蔣琳, 武漢大學(xué)人民醫(yī)院檢驗科 湖北省武漢市 430060
程景輝, 湖北省嘉魚縣人民醫(yī)院內(nèi)科 437200
張禁, 武漢大學(xué)人民醫(yī)院碩士, 主要從事脂肪肝防治研究.
通訊作者: 譚詩云, 430060, 湖北省武漢市武昌區(qū)解放路238號, 武漢大學(xué)人民醫(yī)院消化內(nèi)科. tanshiyun@medmail.com.cn
電話: 027-88041919-2135
收稿日期: 2007-04-02 修回日期: 2007-07-21
Effects of quercetin on the expression of nuclear factor kappaB in alcoholic fatty liver of rats
Jin Zhang, Shi-Yun Tan, Lin Jiang, Wei-Fang Zhu, Jing-Hui Cheng
Jin Zhang, Shi-Yun Tan, Wei-Fang Zhu, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Lin Jiang, Department of Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Jing-Hui Cheng, Department of Medicine, Renmin Hospital of Jiayu Country, Jiayu 437200, Hubei Province, China
Correspondence to: Shi-Yun Tan, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan 430060, Hubei Province, China. tanshiyun@medmail.com.cn
Received: 2007-04-02 Revised: 2007-07-21
Abstract
AIM: To explore the effect and possible mechanism of quercetin on alcoholic fatty liver (AFL) in rats.
METHODS: Forty-eight male wistar rats were randomly divided into four groups: normal control, model, quercetin and naloxone groups. By the end of the fourth week, all rats were weighed, narcotized, sacrificed, and tested for expression levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and tumor necrosis factor-alpha (TNF-α) in plasma. Liver samples were analyzed for common histopathological changes and the expression of nuclear factor kappaB (NF-κB) was measured by immunohistochemical staining.
RESULTS: Levels of AST, ALT, and TNF-α in plasma were markedly lower in the quercetin and naloxone groups than the model group (quercetin, 150.7 ± 23 ......
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