華夏小蔥制劑對脂肪肝大鼠脂質(zhì)代謝和組織形態(tài)學(xué)的影響
華夏小蔥制劑;脂肪肝;形態(tài)學(xué);脂質(zhì)代謝;全自動生化分析儀;透視電鏡,張介眉,郝建軍,時昭紅,常青,邴飛虹,通訊作者:,EffectsofapreparationofChineseAlliumfistulosumLonthemorphologya
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張介眉, 郝建軍, 時昭紅, 武漢市中西醫(yī)結(jié)合醫(yī)院 湖北省武漢市 430022
常青, 邴飛虹, 湖北中醫(yī)學(xué)院中藥研究所 湖北省武漢市 430061
湖北省衛(wèi)生科研基金項目, No. 2006-63
通訊作者: 張介眉, 430022, 湖北省武漢市中山大道215號, 武漢市中西醫(yī)結(jié)合醫(yī)院院長辦公室. zhangjiemei88@126.com
電話: 027-85332516 傳真: 027-85332516
收稿日期: 2007-02-07 修回日期: 2007-07-17
Effects of a preparation of Chinese Allium fistulosum L on the morphology and metabolism of lipids in fatty liver rats
Jie-Mei Zhang, Jian-Jun Hao, Shao-Hong Shi, Qing Chang, Fei-Hong Bing
Jian-Jun Hao, Jie-Mei Zhang, Shao-Hong Shi, Wuhan Integrated Hospital of Traditional Chinese Medicine and Western Medicine, Wuhan 430022, Hubei Province, China
Qing Chang, Fei-Hong Bing, Institute of Traditional Chinese Medicine, College of Traditional Chinese Medicine in Hubei Province, Wuhan 430061, Hubei Province, China
Supported by: the Research Foundation of Public Health of Hubei Province, No. 2006-63
Correspondence to: Jie-Mei Zhang, Wuhan Integrated Hospital of Traditional Chinese Medicine and Western Medicine, 215 Zhongshan Road, Wuhan 430022, Hubei Province, China. zhangjiemei88@126.com
Received: 2007-02-07 Reviesd: 2007-07-17
Abstract
AIM: To study the preventive and therapeutic effects of a preparation of Chinese Allium fistulosum L (PCAL) on fatty liver rats.
METHODS: Sixty sprague–dawley rats were randomly divided into six groups; a blank control group (n = 10), model control group (n = 10), low-, medium- and high-dose PCAL (PCAL low, PCAL medium and PCAL high, respectively, n = 10 in each group), and a Dongbaogantai group (n = 10). The blank control group was given water and food. Other groups were fed with a high-fat diet, given water with 15% ethanol, and treated with a small dose of carbon tetrachloride (CCl4) hypodermically once a week to establish the fatty liver model. All animals were sacrificed after 8 wk. Plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB), globulin (GLO), and A/G (albumin/globulin) were determined by an automatic biochemistry analyzer ......
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