蛋白芯片技術(shù)對肝細(xì)胞癌組織蛋白譜的建立及標(biāo)志蛋白的篩選
基質(zhì)輔助激光解吸附電離;肝細(xì)胞癌;組織蛋白譜,李冬,張建中,鄭燕華,紀(jì)小龍,舒清明,范麗娜,尤紅,李享春,通訊作者:,Usingproteinchiptechnologytoscreenfortissueproteomicprofile
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李冬, 張建中, 鄭燕華, 中國人民解放軍306醫(yī)院病理科 北京市 100101
紀(jì)小龍, 舒清明, 范麗娜, 中國人民解放軍武警總醫(yī)院病理科 北京市 100080
尤紅, 北京友誼醫(yī)院肝病研究中心 北京市100053
李享春, 中國人民解放軍裝備指揮技術(shù)學(xué)院士官系門診部 北京市 102249
李冬, 2002年畢業(yè)于第四軍醫(yī)大學(xué), 2004-07/2007-06于航天醫(yī)學(xué)研究所攻讀醫(yī)學(xué)碩士, 主要從事航天分子病理學(xué)的
研究.
通訊作者: 張建中, 100101, 北京市安翔北路9號, 中國人民解放軍306醫(yī)院病理科. zhangjz55@sina.com
電話: 010-66356237 傳真: 010-64871261
收稿日期: 2007-04-14 修回日期: 2007-07-21
Using protein chip technology to screen for tissue proteomic profiles and tumor markers in hepatocellular carcinoma
Dong Li, Jian-Zhong Zhang, Yan-Hua Zheng, Xiao-Long Ji, Hong You, Qing-Ming Shu, Li-Na Fan, Xiang-Chun Li
Dong Li, Jian-Zhong Zhang, Yan-Hua Zheng, Department of Pathology, 306 Hospital of Chinese PLA, Beijing 100101, China
Xiao-Long Ji, Qing-Ming Shu, Li-Na Fan, Department of Pathology, General Hospital of Armed Police Force of Chinese PLA, Beijing 100080, China
Hong You, Research Center of Liver Disease, Beijing Friendship Hospital, Beijing 100053, China
Xiang-Chun Li, Department of Sergeant, The Academy of Equipment Command and Technology of Chinese PLA, Beijing 102249, China
Correspondence to: Jian-Zhong Zhang, Department of Pathology, 306 Hospital of Chinese PLA, 9 Anxiang North Road, Beijing 100101, China. zhangjz55@sina.com
Received: 2007-04-14 Revised: 2007-07-21
Abstract
AIM: To use the surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technique to screen for tissue biomarkers in patients with hepatocellular carcinoma (HCC), but with different clinicopathological features.
METHODS: Proteomic spectra were examined and analyzed by mass spectroscopy in 44 cases, including 26 specimens of HCC tissue that had been pathologically confirmed in patients aged 34–68 years, and 18 specimens of liver cirrhosis tissue in patients aged 38–70 years. The spectra obtained were analyzed using the biomarker wizard system, and the biomarkers were defined by searching www ......
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