胃黏膜保護(hù)的研究進(jìn)展(6)
4.甘草提取物:生胃酮(carbenoxolone)是自甘草中提取的甘草酸經(jīng)水解衍化而來(lái)。可能的作用機(jī)制包括:增加胃粘液的生成、分泌和黏度;抑制胃蛋白酶的活性;延長(zhǎng)胃黏膜細(xì)胞的壽命;保護(hù)胃黏膜免受膽汁的損害。生胃酮主要在胃內(nèi)吸收,對(duì)胃潰瘍的療效好于十二指腸潰瘍。常用劑量100mg,一日3次,以后逐漸減量維持。副作用為水鈉潴留引起的癥狀。
5.替普瑞酮(teprenone):為萜烯類(lèi)衍生物,對(duì)各種實(shí)驗(yàn)性潰瘍及胃黏膜病變有較強(qiáng)的抗?jié)冏饔煤臀葛つげ∽兊母纳谱饔谩W饔脵C(jī)制包括:促進(jìn)胃黏膜和粘液中高分子糖蛋白合成與分泌;增加疏水層磷脂含量;提高胃粘液中的重碳酸鹽濃度;增加局部?jī)?nèi)源性前列腺素的生成,提高應(yīng)激狀態(tài)下胃黏膜的血流量;促進(jìn)黏膜表面上皮細(xì)胞再生。施維舒(selbex)常用劑量50mg,一日3次,6.麥滋林-S:為水溶性?shī)W(苷菊環(huán)烴、甘菊藍(lán)和Azulene)和L-谷氨酰胺的復(fù)方制劑。苷菊環(huán)烴是從菊科植物花中提取的,有以下作用:抑制多種致炎物質(zhì)引起的炎癥;通過(guò)局部直接作用,抑制炎癥細(xì)胞釋放組胺;增加黏膜內(nèi)前列腺素E2和生長(zhǎng)抑素的合成,促進(jìn)肉芽組織形成和上皮再生;降低胃蛋白酶的活性。L-谷氨酰胺具有增加葡萄糖胺、氨基己糖、粘蛋白的生物合成和促進(jìn)潰瘍組織再生的作用。兩者合用,有利于黏膜組織的修復(fù)和保護(hù)性因子的形成。其作用特點(diǎn)是對(duì)潰瘍面的局部作用,與H2受體拮抗劑聯(lián)合使用療效增強(qiáng)。常用劑量1.5-2.0g,分3~4次,餐后服用。
, 百拇醫(yī)藥
7.思密達(dá)(smecta)其有效成分為雙八面蒙脫石,是一種天然的硅鋁酸鹽。覆蓋消化道,與粘液蛋白結(jié)合,從質(zhì)和量?jī)煞矫嬖鰪?qiáng)黏膜屏障,防止胃酸、胃蛋白酶、膽鹽、NSAID、細(xì)菌及其毒素對(duì)胃腸道黏膜的損害。同時(shí)吸附消化道氣體及各種攻擊因子。
參考文獻(xiàn):
1.Kerss S, Allen A, Garner A, et al. Simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa; Influence of feeding, prostaglandin, N-acetylcysteine and other agent. Clin Sci, 1982,63:187.
2.Shirai Y, Wakatsuki Y, Kusumoto T, et al. Induction and maintenance of immune effector cells in the gastric tissue of mice orally immunized to Helicobacter Pylori requires salivary glands. Gastroenterology, 2000,118(4): 749-759.
, 百拇醫(yī)藥
3.MacAdam AB, Shafi ZB, Marriott C, et al. Anti-mucus polycolonal antibody production purification and linkage to the surface of albumin microspheres. In J Pharm, 2000,15; 195:(12):147-158.
4.Kao YC, Lichtenberger LM, et al. Effect of 16, 16-dimethyl prostaglandin E2 on lipidic organ of rat gastric surface mucous cells. Gastroenterology,1993, 104(1):103-113
5.Chen CM, Chang A, Thomas B,et al. Apical acidification induces paracellular injury in canine gastric mucosal monolayers. Am J Physiol, 1994,267(6Ptl):G1012-1020
6.Robert A, Nezamis JE, Lancaster C, et al. Mild irritants prevent gastric necrosis through “adaptive cytoprotection” mediated by prostaglandings. Am J Physiol, 1983;245:G113, 百拇醫(yī)藥(林三仁)
5.替普瑞酮(teprenone):為萜烯類(lèi)衍生物,對(duì)各種實(shí)驗(yàn)性潰瘍及胃黏膜病變有較強(qiáng)的抗?jié)冏饔煤臀葛つげ∽兊母纳谱饔谩W饔脵C(jī)制包括:促進(jìn)胃黏膜和粘液中高分子糖蛋白合成與分泌;增加疏水層磷脂含量;提高胃粘液中的重碳酸鹽濃度;增加局部?jī)?nèi)源性前列腺素的生成,提高應(yīng)激狀態(tài)下胃黏膜的血流量;促進(jìn)黏膜表面上皮細(xì)胞再生。施維舒(selbex)常用劑量50mg,一日3次,6.麥滋林-S:為水溶性?shī)W(苷菊環(huán)烴、甘菊藍(lán)和Azulene)和L-谷氨酰胺的復(fù)方制劑。苷菊環(huán)烴是從菊科植物花中提取的,有以下作用:抑制多種致炎物質(zhì)引起的炎癥;通過(guò)局部直接作用,抑制炎癥細(xì)胞釋放組胺;增加黏膜內(nèi)前列腺素E2和生長(zhǎng)抑素的合成,促進(jìn)肉芽組織形成和上皮再生;降低胃蛋白酶的活性。L-谷氨酰胺具有增加葡萄糖胺、氨基己糖、粘蛋白的生物合成和促進(jìn)潰瘍組織再生的作用。兩者合用,有利于黏膜組織的修復(fù)和保護(hù)性因子的形成。其作用特點(diǎn)是對(duì)潰瘍面的局部作用,與H2受體拮抗劑聯(lián)合使用療效增強(qiáng)。常用劑量1.5-2.0g,分3~4次,餐后服用。
, 百拇醫(yī)藥
7.思密達(dá)(smecta)其有效成分為雙八面蒙脫石,是一種天然的硅鋁酸鹽。覆蓋消化道,與粘液蛋白結(jié)合,從質(zhì)和量?jī)煞矫嬖鰪?qiáng)黏膜屏障,防止胃酸、胃蛋白酶、膽鹽、NSAID、細(xì)菌及其毒素對(duì)胃腸道黏膜的損害。同時(shí)吸附消化道氣體及各種攻擊因子。
參考文獻(xiàn):
1.Kerss S, Allen A, Garner A, et al. Simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa; Influence of feeding, prostaglandin, N-acetylcysteine and other agent. Clin Sci, 1982,63:187.
2.Shirai Y, Wakatsuki Y, Kusumoto T, et al. Induction and maintenance of immune effector cells in the gastric tissue of mice orally immunized to Helicobacter Pylori requires salivary glands. Gastroenterology, 2000,118(4): 749-759.
, 百拇醫(yī)藥
3.MacAdam AB, Shafi ZB, Marriott C, et al. Anti-mucus polycolonal antibody production purification and linkage to the surface of albumin microspheres. In J Pharm, 2000,15; 195:(12):147-158.
4.Kao YC, Lichtenberger LM, et al. Effect of 16, 16-dimethyl prostaglandin E2 on lipidic organ of rat gastric surface mucous cells. Gastroenterology,1993, 104(1):103-113
5.Chen CM, Chang A, Thomas B,et al. Apical acidification induces paracellular injury in canine gastric mucosal monolayers. Am J Physiol, 1994,267(6Ptl):G1012-1020
6.Robert A, Nezamis JE, Lancaster C, et al. Mild irritants prevent gastric necrosis through “adaptive cytoprotection” mediated by prostaglandings. Am J Physiol, 1983;245:G113, 百拇醫(yī)藥(林三仁)
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