急性心肌梗死靜脈溶栓治療(2)
二、 溶栓時間窗

從多項臨床試驗的數(shù)據(jù)中描出入選溶栓時間與死亡率下降的曲線?梢姷50%以上的死亡率下降發(fā)生在癥狀發(fā)作后第一個黃金小時(golden first hour)。此后死亡率下降的得益降到平臺期,約下降25%直到發(fā)病后12小時。12小時后,用溶栓療法未能證明得到顯著的存活益處。圖中試驗縮寫為:AIMS=Anistreplase Intervention Mortality Study, ASSET=Anglo-Scandinavian Study of Early Thrombolysis, EMERAS=Estudio Multicentrico Estreptoquinasa Studio della Streptochinasi nell' Infartl Miocardico, ISIS-2=Second International Study of Infarct Survival, LATE=Late Assessment of Thrombolytic Efficacy, MITI=Myocardial Infarction and Triage Intervention Project, (來自Lincoff AM, Topol EJ. The illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation. 1993; 87: 1792~1805), http://www.www.srpcoatings.com(李海燕)
從多項臨床試驗的數(shù)據(jù)中描出入選溶栓時間與死亡率下降的曲線?梢姷50%以上的死亡率下降發(fā)生在癥狀發(fā)作后第一個黃金小時(golden first hour)。此后死亡率下降的得益降到平臺期,約下降25%直到發(fā)病后12小時。12小時后,用溶栓療法未能證明得到顯著的存活益處。圖中試驗縮寫為:AIMS=Anistreplase Intervention Mortality Study, ASSET=Anglo-Scandinavian Study of Early Thrombolysis, EMERAS=Estudio Multicentrico Estreptoquinasa Studio della Streptochinasi nell' Infartl Miocardico, ISIS-2=Second International Study of Infarct Survival, LATE=Late Assessment of Thrombolytic Efficacy, MITI=Myocardial Infarction and Triage Intervention Project, (來自Lincoff AM, Topol EJ. The illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation. 1993; 87: 1792~1805), http://www.www.srpcoatings.com(李海燕)
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