清熱利濕益氣活血法降血尿酸及對(duì)腎損害的保護(hù)作用
熊湘明1,曲竹秋2,賈錫鏈2,李沛霖2(1.天津公安醫(yī)院,天津 300050; 2.天津醫(yī)科大學(xué)總醫(yī)院,天津 300040)
【摘要】 目的:觀察清熱利濕、益氣活血法對(duì)實(shí)驗(yàn)性高尿酸血癥腎損害大鼠血清尿酸水平、腎功能及腎損害的修復(fù)作用。方法:采用腺嘌呤聯(lián)合乙胺丁醇建立動(dòng)物模型,設(shè)立中藥復(fù)方組、模型組、西藥組與正常對(duì)照組,檢測(cè)實(shí)驗(yàn)前及實(shí)驗(yàn)后第7、14和21 d的血清尿酸、尿素氮(BUN)、肌酐(SCr)水平,行腎組織超微病理學(xué)觀察。結(jié)果:清熱利濕、益氣活血中藥具有降低血清尿酸的作用,其第14 d和21 d血清尿酸水平與模型組比較均明顯降低(P均<0.05);能改善高尿酸血癥腎損害大鼠的腎功能,其SCr、BUN已接近正常水平(P均>0.05);對(duì)高尿酸血癥腎臟病理?yè)p害有修復(fù)作用,電鏡結(jié)果示中藥組大鼠腎臟結(jié)構(gòu)基本正常。結(jié)論:清熱利濕、益氣活血法可降低血尿酸,對(duì)高尿酸血癥腎損害具有預(yù)防及治療作用。
【關(guān)鍵詞】 清熱利濕益氣活血法;高尿酸血癥;腎損害;病理組織學(xué)變化
Effect of agents with actions of clearing away heat and dampness(清熱利濕) and promoting circulation of Qi and blood(益氣活血) protecting renal injury and reducing the level of blood uric acid
XIONG Xiang-ming1, QU Zhu-qiu2, JIA Xi-lian2, LI Pei-lin. 1. Gongan Hospital,Tianjin 300050, China; 2. The General Hospital of Tianjin Medical University, Tianjin 300040, China
【Abstract】 Objective: To observe the repairment effect of agents with actions of clearing away heat and dampness(清熱利濕) and promoting circulation of Qi and blood (益氣活血) on serum uric acid(UA), renal function, as well as protection of kidney injury in rats with hyperuricemia. Methods: Animal model was established by adenine and ethambutol hydrochloride, the rats were then randomly divided into model group, traditional Chinese medicine group, western medicine group, and normal control group. The serum level of UA, blood urea nitrogen (BUN) and serum creatinine (SCr) were measured before the experiment and on the 7 th, 14 th and 21 st day after treatment. The pathologic changes in kidney were observed by electronmicroscope. Results: raditional Chinese medicine of agents with actions of clearing away heat and dampness(清熱利濕)and promoting circulation of Qi and blood(益氣活血) could lower the level of serum UA, and the UA level was lowered significantly than that in the model group at the 14 th and 21 st day (both P<0.05). It could improve the renal function of experimental rats, and the levels of SCr and BUN were nearly to the normal level (both P>0.05). It could also repair the pathological impairment of kidney, further more, under electronmicroscope, no abnormality was found in kidney. Conclusion: The therapy for clearing away heat and dampness and promating circulation of Qi and the blood can prevent and cure the renal injury in experimental hyperuricemic rats by lowing UA. ......
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