清氮灌腸液治療慢性腎功能衰竭的臨床研究
郭兆安1,武文斌2,姜錫斌1,焦安欽1(1.山東中醫(yī)藥大學(xué)附屬醫(yī)院,山東濟(jì)南 250011; 2.山東省濰坊市益都中心醫(yī)院,山東 濰坊 262500)
【摘要】 目的:觀察清氮灌腸液治療慢性腎功能衰竭(CRF)的臨床療效并探討其作用機(jī)制。方法:194例CRF住院患者以2∶1的比例隨機(jī)分為治療組和對照組,治療組128例用清氮灌腸液治療,對照組66例用包醛氧化淀粉治療;除觀察兩組治療前后癥狀、體征和腎功能相關(guān)指標(biāo)外,還觀察了中分子物質(zhì)(MMS)、甲狀旁腺激素(PTH)、血鈣(SCa)、血磷(SP)等變化。結(jié)果:治療組經(jīng)清氮灌腸液治療后,患者癥狀、體征積分明顯下降(P<0.05),對照組下降不明顯(P>0.05);治療組用藥后MMS、PTH、SCa、SP均較治療前改善(P<0.05或P<0.01),而對照組無明顯改善(P>0.05)。治療組顯效74例,有效38例,無效16例,總有效率87.5%;對照組顯效18例,有效26例,無效22例,總有效率66.7%;兩組療效比較差異有顯著性(χ2=11.72, P<0.01)。結(jié)論:清氮灌腸液治療CRF有較好的療效,其機(jī)制可能與降低MMS和PTH以及改善鈣、磷代謝障礙有關(guān)。
【關(guān)鍵詞】 腎功能衰竭,慢性;中醫(yī)藥治療;灌腸;中分子物質(zhì);甲狀旁腺激素
Clinical study on the Qingdan Guanchang liquid(清氮灌腸液) in treatment of chronic renal failure
GUO Zhao-an1, WU Wen-bin2, JIANG Xi-bin1, JIAO An-qin1. 1. The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, Shandong, China; 2. Yidu Central Hospital, Weifang 262500, Shandong, China
【Abstract】 Objective: To observe the clinical efficacy of Qingdan Guanchang liquid (清氮灌腸液) for treatment of chronic renal failure (CRF) and explore its potential mechanism. Methods:One hundred and ninety-four patients with CRF were divided randomly into two groups with the ratio of 2∶1, the therapeutic group and the control group. Patients in the therapeutic group (128 cases) were administered with Qingdan Guanchang liquid, while those in the control group (66 cases) treated with coated aldehyde oxystarch. Besides the observations on the changes of the clinical symptoms, signs and renal function before and after the treatment, middle molecular substance(MMS), parathyroid hormone (PTH), serum calcium(SCa) and serum phosphorus(SP) were measured in the two groups. Results: Accumulated score of clinical symptoms and signs were decreased after treatment with Qingdan Guanchang liquid (P<0.05), but no significant changes were seen in the control group (P>0.05); MMS, PTH, SCa and SP were improved after treatment in the therapeutic group (P<0.05 or P<0.01), but no changes were found in the control group (P>0.05). In the therapeutic group, 74 cases were remarkably improved, 38 cases were effectives, and 16 cases had no effect, the total effective rate being 87.5%, and they were 18 cases, 26 cases, and 22 cases, 66.7% respectively in the control group. The difference of the clinical efficacy was significantly between the two groups (χ2=11.72, P<0.01). Conclusion: Qingdan Guanchang liquid has a good therapeutic effect for the treatment of CRF. The potential mechanism may be related to the decrease of MMS, PTH and the improvement of metabolic disorder of calcium and phosphorus. ......
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