IgA腎病5型辨證與微觀辨證的相關(guān)性研究(1)
摘要目的:觀察IgA腎病五型辨證與腎臟病理的相關(guān)性,探索IgA腎病中醫(yī)微觀辨證依據(jù)。方法:選取2012年1月至2013年2月浙江中醫(yī)藥大學(xué)附屬?gòu)V興醫(yī)院收治的符合入選標(biāo)準(zhǔn)的原發(fā)性IgA腎病患者373例,收集患者一般情況,中醫(yī)四診及辨證分型、腎病理資料,分析比較IgA腎病五型辨證與腎臟病理的相關(guān)性。結(jié)果:373例原發(fā)性IgA腎病患者常見證候是腎虛證、腎虛證+瘀痹證、單獨(dú)瘀痹證、單獨(dú)風(fēng)濕證、風(fēng)濕證+瘀痹證和肝風(fēng)證+風(fēng)濕證6種。免疫熒光提示單獨(dú)風(fēng)濕證、風(fēng)濕證+肝風(fēng)證均和C1q沉積具有一定的相關(guān)性。Katafuchi評(píng)分可作為IgA腎病五型辨證的微觀辨證參數(shù),積分高低可以反映病機(jī)的演變與發(fā)展。含有風(fēng)濕證的IgA腎病牛津分型積分高,提示腎臟病理活動(dòng)性大,病情易進(jìn)展迅速。結(jié)論:IgA腎病五型辨證分型與免疫熒光C1q沉積、Katafuchi評(píng)分及牛津分型等大部分腎臟病理指標(biāo)具有相關(guān)性。
關(guān)鍵詞IgA腎;中醫(yī)證候;微觀辨證
Correlation Study between Five Syndrome Differentiation and Microscopic Syndrome Differentiation of IgA Nephropathy
, http://www.www.srpcoatings.com
Chen Hongyu, Yu Dongrong, Zhang Minou, Hu Yunqin, Zhou Liusha, Wang Xiaowei, Zeng Jiali
(Guangxing Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, China)
AbstractObjective:To observe the correlation between TCM syndrome differentiation of IgA nephropathy and renal pathology, and explore the basis of TCM microcosmic syndrome differentiation. Methods:A total of 373 patients with primary IgA nephropathy in our hospital from January 2012 to February 2013 were enrolled in the study. The general data of patients, the four diagnoses and syndrome differentiation of TCM, and the pathological data of nephropathy were collected to analyze the correlation between the syndrome differentiation of IgA nephropathy and renal pathology. Results:The common TCM syndromes of 373 IgA nephropathy patients were kidney deficiency syndrome, kidney deficiency with stasis bi syndrome, stasis bi syndrome, winddampness syndrome, winddampness and stasis bi syndrome, and the liver wind syndrome and winddampness syndrome. Immunofluorescence suggested that there was certain correlation between winddampness syndrome, winddampness and liver wind syndrome and C1q deposition. Katafuchi score could be used as the microcosmic parameter of IgA nephropathy TCM syndrome differentiation, and the score level could reflect the evolution and development of pathogenesis. IgA nephropathy with winddampness syndrome had a high score of Oxford classification, which suggested that the renal pathological activity was high and the disease was easy to progress rapidly. Conclusion:The TCM syndrome differentiation of IgA nephropathy is correlated with most renal pathological indexes such as immunofluorescence C1q deposition, Katafuchi score and Oxford classification.
Key WordsIgA nephropathy; TCM syndrome; Microcosmic syndrome differentiation
中圖分類號(hào):R2565文獻(xiàn)標(biāo)識(shí)碼:Adoi:10.3969/j.issn.1673-7202.2018.07.052, 百拇醫(yī)藥(陳洪宇 俞東容 張敏鷗 胡云琴 周柳沙 王曉偉 曾佳麗)
關(guān)鍵詞IgA腎;中醫(yī)證候;微觀辨證
Correlation Study between Five Syndrome Differentiation and Microscopic Syndrome Differentiation of IgA Nephropathy
, http://www.www.srpcoatings.com
Chen Hongyu, Yu Dongrong, Zhang Minou, Hu Yunqin, Zhou Liusha, Wang Xiaowei, Zeng Jiali
(Guangxing Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, China)
AbstractObjective:To observe the correlation between TCM syndrome differentiation of IgA nephropathy and renal pathology, and explore the basis of TCM microcosmic syndrome differentiation. Methods:A total of 373 patients with primary IgA nephropathy in our hospital from January 2012 to February 2013 were enrolled in the study. The general data of patients, the four diagnoses and syndrome differentiation of TCM, and the pathological data of nephropathy were collected to analyze the correlation between the syndrome differentiation of IgA nephropathy and renal pathology. Results:The common TCM syndromes of 373 IgA nephropathy patients were kidney deficiency syndrome, kidney deficiency with stasis bi syndrome, stasis bi syndrome, winddampness syndrome, winddampness and stasis bi syndrome, and the liver wind syndrome and winddampness syndrome. Immunofluorescence suggested that there was certain correlation between winddampness syndrome, winddampness and liver wind syndrome and C1q deposition. Katafuchi score could be used as the microcosmic parameter of IgA nephropathy TCM syndrome differentiation, and the score level could reflect the evolution and development of pathogenesis. IgA nephropathy with winddampness syndrome had a high score of Oxford classification, which suggested that the renal pathological activity was high and the disease was easy to progress rapidly. Conclusion:The TCM syndrome differentiation of IgA nephropathy is correlated with most renal pathological indexes such as immunofluorescence C1q deposition, Katafuchi score and Oxford classification.
Key WordsIgA nephropathy; TCM syndrome; Microcosmic syndrome differentiation
中圖分類號(hào):R2565文獻(xiàn)標(biāo)識(shí)碼:Adoi:10.3969/j.issn.1673-7202.2018.07.052, 百拇醫(yī)藥(陳洪宇 俞東容 張敏鷗 胡云琴 周柳沙 王曉偉 曾佳麗)
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