脈絡(luò)舒通丸聯(lián)合鹽酸沙格雷酯治療血栓閉塞性脈管炎的臨床療效觀察(1)
摘要 目的:觀察并分析脈絡(luò)舒通丸聯(lián)合鹽酸沙格雷酯治療血栓閉塞性脈管炎(TAO)的臨床療效。方法:選取2016年8月至2018年8月湖北省荊門市第二人民醫(yī)院收治的血栓閉塞性脈管炎患者102例作為研究對象,按照隨機數(shù)字表法隨機分為對照組和觀察組,每組51例。對照組患者給予鹽酸沙格雷酯片口服治療,觀察組患者給予鹽酸沙格雷酯片聯(lián)合脈絡(luò)舒通丸口服治療。觀察并分析2組患者的治療效果。結(jié)果:觀察組總有效率為88.24%,對照組總有效率為80.39%,2組比較差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論:脈絡(luò)舒通丸聯(lián)合鹽酸沙格雷酯可有效緩解血栓閉塞性脈管炎患者的主要臨床癥狀,改善血液流變學(xué)指標(biāo),治愈率較高,療效顯著。
關(guān)鍵詞 脈絡(luò)舒通丸;鹽酸沙格雷酯;血栓閉塞性脈管炎(TAO);臨床療效
Clinical Observation on Effects of Mailuo Shutong Pills Combined with Sarpogrelate Hydrochloride on the Treatment of Thromboangiitis Obliterans
Li Ling1,Song Yi2,Sun Chenglei2,Shang Suzhen2,Li Xiang2
(1 Department of Pharmacy,Jingmen No.2 People′s Hospital,Jingmen 448000,China; 2 State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine,Linyi 276000,China)
Abstract Objective:To observe and analyze the clinical effect of Mailuo Shutong Pills combined with sarpogrelate hydrochloride in the treatment of thromboangiitis obliterans(TAO).Methods:From August,2016 to August,2018,102 patients with thromboangiitis obliterans admitted to Jingmen No.2 People′s Hospital who met the inclusion criteria were selected as the study subjects,and were randomly divided into a control group and an observation group according to the random number table method,with 51 patients in each group.Patients in the control group were given oral treatment of sarpogrelate hydrochloride tablets,while those in the observation group were given oral treatment of sarpogrelate hydrochloride tablets combined with Mailuo Shutong Pills.The therapeutic effects of the 2 groups were observed and analyzed.Results:The total effective rate in the observation group was 88.24%,and that in the control group was 80.39% and the difference between the 2 groups was statistically significant(P<0.05).Conclusion:Mailuo Shutong Pill combined with sarpogrelate hydrochloride can effectively alleviate the main clinical symptoms of TAO patients,improve the hemorheology indexes,and have a high cure rate and significant curative effect.
Key Words Mailuo Shutong Pills; Sarpogrelate hydrochloride; Thromboangiitis obliterans(TAO); Clinical curative effect
中圖分類號:R242;R285.6文獻標(biāo)識碼:Adoi:10.3969/j.issn.1673-7202.2019.09.020
血栓閉塞性脈管炎(Thromboangiitis Obliterans,TAO)是一種主要損傷四肢遠端中小動靜及淺靜脈的周圍血管炎性反應(yīng)和由血栓形成導(dǎo)致的閉塞性病變[1-2],通常出現(xiàn)在下肢,可侵襲血管全層,致使管腔狹窄、閉塞,會造成嚴(yán)重癥狀和體征,具有慢性、進行性、持續(xù)性和階段性的特點,但不存在或極少存在粥樣硬化[3-4]。常見于有重度嗜煙史的青壯年男性,且多在氣溫較低的冬季發(fā)病,女性、老年較為少見,在我國發(fā)病率較高,是常見的周圍血管病之一[5]。其發(fā)病機制尚不完全清楚,多認為與交感神經(jīng)功能紊亂,使血管容易痙攣,也可能與某些引起的自身免疫反應(yīng)的病原生物有關(guān)[6],目前國內(nèi)外研究認為吸煙是TAO的誘因,在這種疾病的患者中,吸煙人員的比例高達60%~90%[7-8]。除吸煙外,遺傳、內(nèi)分泌紊亂、創(chuàng)傷、病毒或真菌感染、潮濕、寒冷、營養(yǎng)不良等也可能是發(fā)病的誘因。, http://www.www.srpcoatings.com(李玲 宋毅 孫成磊 商素珍 李祥)
關(guān)鍵詞 脈絡(luò)舒通丸;鹽酸沙格雷酯;血栓閉塞性脈管炎(TAO);臨床療效
Clinical Observation on Effects of Mailuo Shutong Pills Combined with Sarpogrelate Hydrochloride on the Treatment of Thromboangiitis Obliterans
Li Ling1,Song Yi2,Sun Chenglei2,Shang Suzhen2,Li Xiang2
(1 Department of Pharmacy,Jingmen No.2 People′s Hospital,Jingmen 448000,China; 2 State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine,Linyi 276000,China)
Abstract Objective:To observe and analyze the clinical effect of Mailuo Shutong Pills combined with sarpogrelate hydrochloride in the treatment of thromboangiitis obliterans(TAO).Methods:From August,2016 to August,2018,102 patients with thromboangiitis obliterans admitted to Jingmen No.2 People′s Hospital who met the inclusion criteria were selected as the study subjects,and were randomly divided into a control group and an observation group according to the random number table method,with 51 patients in each group.Patients in the control group were given oral treatment of sarpogrelate hydrochloride tablets,while those in the observation group were given oral treatment of sarpogrelate hydrochloride tablets combined with Mailuo Shutong Pills.The therapeutic effects of the 2 groups were observed and analyzed.Results:The total effective rate in the observation group was 88.24%,and that in the control group was 80.39% and the difference between the 2 groups was statistically significant(P<0.05).Conclusion:Mailuo Shutong Pill combined with sarpogrelate hydrochloride can effectively alleviate the main clinical symptoms of TAO patients,improve the hemorheology indexes,and have a high cure rate and significant curative effect.
Key Words Mailuo Shutong Pills; Sarpogrelate hydrochloride; Thromboangiitis obliterans(TAO); Clinical curative effect
中圖分類號:R242;R285.6文獻標(biāo)識碼:Adoi:10.3969/j.issn.1673-7202.2019.09.020
血栓閉塞性脈管炎(Thromboangiitis Obliterans,TAO)是一種主要損傷四肢遠端中小動靜及淺靜脈的周圍血管炎性反應(yīng)和由血栓形成導(dǎo)致的閉塞性病變[1-2],通常出現(xiàn)在下肢,可侵襲血管全層,致使管腔狹窄、閉塞,會造成嚴(yán)重癥狀和體征,具有慢性、進行性、持續(xù)性和階段性的特點,但不存在或極少存在粥樣硬化[3-4]。常見于有重度嗜煙史的青壯年男性,且多在氣溫較低的冬季發(fā)病,女性、老年較為少見,在我國發(fā)病率較高,是常見的周圍血管病之一[5]。其發(fā)病機制尚不完全清楚,多認為與交感神經(jīng)功能紊亂,使血管容易痙攣,也可能與某些引起的自身免疫反應(yīng)的病原生物有關(guān)[6],目前國內(nèi)外研究認為吸煙是TAO的誘因,在這種疾病的患者中,吸煙人員的比例高達60%~90%[7-8]。除吸煙外,遺傳、內(nèi)分泌紊亂、創(chuàng)傷、病毒或真菌感染、潮濕、寒冷、營養(yǎng)不良等也可能是發(fā)病的誘因。, http://www.www.srpcoatings.com(李玲 宋毅 孫成磊 商素珍 李祥)
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