曲美他嗪對擴張型心肌病心力衰竭患者心功能的療效觀察(1)
 |
| 第1頁 |
參見附件(2057KB，2頁)。
[摘要] 目的：觀察曲美他嗪治療擴張型心肌病(DCM) 合并心力衰竭的臨床價值。方法：100例DCM合并心力衰竭患者隨機分為觀察組和對照組，對照組給予常規(guī)抗心力衰竭治療, 觀察組在常規(guī)治療的基礎上加用曲美他嗪治療。觀察治療前和治療24周后患者心功能分級及左室射血分數(shù)(LVEF)、左室舒張末期內徑(LVEDD)、每分心排量(CO)的變化。結果：治療24周后, 對照組總有效率為72.00%(36/50)，觀察組總有效率為88.00%(44/50)，兩者比較差異有統(tǒng)計學意義(P<0.05)；兩組治療后LVEDD、CO、LVEF均較治療前顯著改善(P<0.01)，且觀察組治療后上述指標明顯優(yōu)于對照組(P<0.01或P<0.05)。結論：曲美他嗪可以安全有效地改善DCM合并心力衰竭患者的心功能，值得臨床推廣。
[關鍵詞] 曲美他嗪；擴張型心肌�。恍牧λソ�；心功能
[中圖分類號] R942.2 [文獻標識碼]B[文章編號]1674-4721(2011)05(c)-062-02
Clinical therapeutic effectiveness of trimetazidine on the treatment of patients with dilated cardiomyopathy associated with chronic congestive heart failure
YANG Haitao, ZHENG Huafeng, HUANG Peng
Cardiology-vesicular Department, Shenzhen Hospital Peking University， Guangdong Province, Shenzhen 518036,China
[Abstract] Objective: To explore the clinical therapeutic effectiveness of trimetazidine on the treatment of dilated cardiomyopathy( DCM) associated with chronic congestive heart failure(CHF). Methods: 100 patients with DCM associated with CHF were randomly divided into control group and observation group. Patients in the control group were given routinely treated. Patients in the observation group were treated with trimetazidine on the basis of the routine treatment. The course of treatment lasted 24 weeks. The grade of cardiac function, left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter (LVEDD) and cardiac output (CO)were determined before and after 24 weeks after treatment in both groups. Results:After 24 weeks of treatment, the total effective rate in the control group was 72.00% (36/50), and in the observation group was 88.00% (44/50), the difference was statistically significant(P<0.05); Both groups the level of LVEDD, CO, LVEF were significantly improved compared with before the treatment(P<0.01), and the index in the observation group were better than the control group(P<0.01 or P<0.05). Conclusion: For patients with dilated cardiomyopathy, long-time treatment with trimetazidine in combination with routine therapy can significantly improve the left cardiac function ......
您現(xiàn)在查看是摘要介紹頁，詳見PDF附件(2057KB，2頁)。