乳腺癌保乳術(shù)后全乳放療三種計劃劑量學比較分析(1)
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[摘要] 目的 比較左乳腺癌保乳術(shù)后采用常規(guī)(RT)、三維適形放射治療(3DCRT)和調(diào)強放療(IMRT)三種不同照射方法的劑量學差異。 方法 選擇10例接受保乳手術(shù)的左側(cè)早期乳腺癌患者，應(yīng)用Eclipse 7.3計劃系統(tǒng)為每例患者分別設(shè)計常規(guī)、3DCRT和5野逆向IMRT三套放療計劃，均給予50 Gy/25次，比較靶區(qū)、正常組織的受照劑量差異。 結(jié)果 IMRT計劃的劑量分布以及靶區(qū)適形性和均勻性均顯著優(yōu)于常規(guī)和3DCRT計劃。RT、3DCRT、IMRT計劃中患側(cè)肺的V20分別為(29.4±4.6)%、(26.7±4.6)%、(22.6±1.8)%；患側(cè)肺的V30分別為(26.4±5.2)%、(23.4±4.5)%、(16.2±1.6)%；心臟V30分別為(21.9±6.0)%、(14.6±3.5)%、(8.0±3.8)%，差異均具有統(tǒng)計學意義。 結(jié)論 與常規(guī)(RT)、3DCRT切線野計劃相比，5野IMRT計劃可以顯著改善靶區(qū)的劑量分布，降低危及器官OARs(肺及心臟)高劑量受照體積，更好地保護心、肺組織，但同時增大了正常組織低劑量區(qū)受照體積。
[關(guān)鍵詞] 乳腺腫瘤；放射療法；三維適形放射治療；調(diào)強放射治療；劑量學
[中圖分類號] R737.9 [文獻標識碼] A [文章編號] 1674-4721(2012)02(a)-0007-03
Comparison and analysis of dosimetry in three kind of plan of whole breast radiation therapy after breast-conservation treatment in breast cancer
HAN Baoshan1 ZHANG Li2 QIAO Li1 CHEN Ming2
1. Radiation Center, Yantai Tumor Hospital of Yantai City in Shandong Province, Yantai 264025, China; 2. Tumor Hospital Affiliated Sun Yat-Sen University in Guangdong Province, Guangzhou 510060, China
[Abstract] Objective To compare the dosimetric distribution between conventional radiotherapy (RT), three-dimensional cnformal radiotherapy (3DCRT), and intensity-modulated radiotherapy (IMRT) for left-sided whole breast treatment. Methods Ten patients with left-sided breast-conserving surgery and whole breast irradiation were selected. For each patient, the RT, 3DCRT and IMRT with 5 fields were prepared using Eclipse 7.3 treatment planning system. Prescription dose was set to 50 Gy to planning target volume (PTV) in 25 fractions. PTV dose coverage and dose to normal tissues were evaluated. Results Compared with RT and 3DCRT plans, IMRT provided a significant improvement in PTV dose coverage, conformity and homogeneity. The V20 of ipsilateral lung was (29.4±4.6)% (RT), (26.7±4.6)% (3DCRT), and (22.6±1.8)% (IMRT), respectively ......
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