別嘌呤醇治療急性腦梗死伴高尿酸血癥的臨床效果(1)
[摘要] 目的 探討別嘌呤醇治療急性腦梗死伴高尿酸血癥的臨床效果。 方法 選取2013年10月～2014年10月本院收治的80例急性腦梗死伴高尿酸血癥患者作為研究對象，隨機(jī)分為對照組和觀察組，各40例。對照組給予抗凝、抗血小板聚集等對癥治療，觀察組在對照組的基礎(chǔ)上給予別嘌呤醇，比較兩組治療前后的血清尿酸水平、神經(jīng)功能缺損評分以及臨床效果。 結(jié)果 兩組治療后的血清尿酸水平與神經(jīng)功能缺損評分顯著低于治療前，差異有統(tǒng)計學(xué)意義(P<0.05)。觀察組治療后的血清尿酸水平與神經(jīng)功能缺損評分顯著低于對照組治療后，差異有統(tǒng)計學(xué)意義(P<0.05)。觀察組的總有效率為92.5%，顯著高于對照組的75.0%，差異有統(tǒng)計學(xué)意義(P<0.05)。 結(jié)論 別嘌呤醇能夠明顯降低急性腦梗死伴高尿酸血癥患者的血清尿酸水平，改善患者的神經(jīng)功能缺損癥狀，值得臨床推廣應(yīng)用。
[關(guān)鍵詞] 別嘌呤醇；高尿酸血癥；急性腦梗死；療效
[中圖分類號] R743.3 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-4721(2015)05(b)-0114-03
Clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia
GUO Jian-jun NI Xiao-jun SHI Li LIU Jiu-di WU Xiao-yan WEI Wei-min
Department of Neurology，People′s Hospital of Zengcheng City in Guangdong Province，Zengcheng 511300，China
[Abstract] Objective To explore the clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia. Methods 80 patients with acute cerebral infarction combined with hyperuricemia from October 2013 to October 2014 in our hospital were selected and randomly divided into the control group and the observation group，40 cases in each group.The control group was given symptomatic treatment like anticoagulant and anti-platelet aggregation，the observation group was treated with allopurinol on the basis of the control group.The level of serum uric acid，the score of neurological function defect and clinical effect before and after treatment in two groups was compared. Results The level of serum uric acid and the score of neurological function defect in two groups after treatment was lower than that before treatment，with significant difference(P<0.05).The level of serum uric acid and the score of neurological function defect in the observation group after treatment was lower than that in the control group after treatment，with significant difference(P<0.05).The total effective rate in the observation group was 92.5%，which was higher than 75.0% in the control group，with significant difference(P<0.05). Conclusion Allopurinol can significantly reduce serum uric acid level and improve symptoms of neurological function defect in patients with acute cerebral infarction combined with hyperuricemia，it is worthy of clinical promotion and application.
[Key words] Allopurinol；Hyperuricemia；Acute cerebral infarction；Efficacy
急性腦梗死是臨床常見的疾病之一，起病急、進(jìn)展快、復(fù)發(fā)率高，具有較高的致殘率和致死率，嚴(yán)重影響患者的生活質(zhì)量及生命安全。近年來的研究顯示，高尿酸血癥與急性腦梗死的發(fā)生、發(fā)展具有密切相關(guān)性[1-3]，當(dāng)血清尿酸水平增高時，急性腦梗死患者的預(yù)后質(zhì)量相對較差。別嘌呤醇作為黃嘌呤氧化酶抑制劑，能夠有效抑制尿酸生成[4]。本研究選取本院的急性腦梗死伴高尿酸血癥患者作為研究對象，探討別嘌呤醇的治療效果。 (郭建軍 倪曉俊 史麗 劉就娣 吳小燕 )
[關(guān)鍵詞] 別嘌呤醇；高尿酸血癥；急性腦梗死；療效
[中圖分類號] R743.3 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-4721(2015)05(b)-0114-03
Clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia
GUO Jian-jun NI Xiao-jun SHI Li LIU Jiu-di WU Xiao-yan WEI Wei-min
Department of Neurology，People′s Hospital of Zengcheng City in Guangdong Province，Zengcheng 511300，China
[Abstract] Objective To explore the clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia. Methods 80 patients with acute cerebral infarction combined with hyperuricemia from October 2013 to October 2014 in our hospital were selected and randomly divided into the control group and the observation group，40 cases in each group.The control group was given symptomatic treatment like anticoagulant and anti-platelet aggregation，the observation group was treated with allopurinol on the basis of the control group.The level of serum uric acid，the score of neurological function defect and clinical effect before and after treatment in two groups was compared. Results The level of serum uric acid and the score of neurological function defect in two groups after treatment was lower than that before treatment，with significant difference(P<0.05).The level of serum uric acid and the score of neurological function defect in the observation group after treatment was lower than that in the control group after treatment，with significant difference(P<0.05).The total effective rate in the observation group was 92.5%，which was higher than 75.0% in the control group，with significant difference(P<0.05). Conclusion Allopurinol can significantly reduce serum uric acid level and improve symptoms of neurological function defect in patients with acute cerebral infarction combined with hyperuricemia，it is worthy of clinical promotion and application.
[Key words] Allopurinol；Hyperuricemia；Acute cerebral infarction；Efficacy
急性腦梗死是臨床常見的疾病之一，起病急、進(jìn)展快、復(fù)發(fā)率高，具有較高的致殘率和致死率，嚴(yán)重影響患者的生活質(zhì)量及生命安全。近年來的研究顯示，高尿酸血癥與急性腦梗死的發(fā)生、發(fā)展具有密切相關(guān)性[1-3]，當(dāng)血清尿酸水平增高時，急性腦梗死患者的預(yù)后質(zhì)量相對較差。別嘌呤醇作為黃嘌呤氧化酶抑制劑，能夠有效抑制尿酸生成[4]。本研究選取本院的急性腦梗死伴高尿酸血癥患者作為研究對象，探討別嘌呤醇的治療效果。 (郭建軍 倪曉俊 史麗 劉就娣 吳小燕 )