輕度認(rèn)知障礙及阿爾茨海默病的sMRI分析(1)
[摘要]目的 探討輕度認(rèn)知障礙(MCI)和阿爾茨海默病(AD)各腦區(qū)結(jié)構(gòu)性磁共振(sMRI)的特征，發(fā)現(xiàn)特征性指標(biāo)，從而為早期診斷提供幫助。方法 隨機(jī)選取2014年8月～2015年7月ADNI數(shù)據(jù)庫(kù)中編號(hào)為4018～5210的研究對(duì)象543例，根據(jù)阿爾茨海默病神經(jīng)影像學(xué)計(jì)劃(ADNI)數(shù)據(jù)庫(kù)診斷標(biāo)準(zhǔn)分為四組：認(rèn)知功能正常組(CN)139例，早期輕度認(rèn)知障礙組(EMCI)220例，晚期輕度認(rèn)知障礙組(LMCI)108例，AD組76例，獲得研究對(duì)象簡(jiǎn)易精神狀態(tài)評(píng)價(jià)量表(mini-mental state examination，MMSE)及272項(xiàng)結(jié)構(gòu)性MRI(structural MRI，sMRI)數(shù)據(jù)。將sMRI數(shù)據(jù)進(jìn)行單因素方差分析、多重比較、非參數(shù)檢驗(yàn)、配對(duì)比較分析、多元線性回歸分析等統(tǒng)計(jì)學(xué)方法，發(fā)現(xiàn)具有疾病預(yù)測(cè)意義的特征指標(biāo)。結(jié)果 272項(xiàng)sMRI數(shù)據(jù)分析，獲得CN、EMCI、LMCI、AD四組間差異均有統(tǒng)計(jì)學(xué)意義的指標(biāo)28項(xiàng)，其中22項(xiàng)為左右腦區(qū)配對(duì)部位。左右腦區(qū)進(jìn)行配對(duì)比較分析，左半球萎縮程度更嚴(yán)重。28項(xiàng)sMRI數(shù)據(jù)與MMSE經(jīng)多元線性回歸分析得出，左海馬下托體積對(duì)MMSE量表評(píng)分影響最大。結(jié)論 隨著MCI發(fā)病向AD進(jìn)展，腦萎縮程度逐漸遞增，且左半球在疾病進(jìn)展中萎縮程度更嚴(yán)重，主要集中在邊緣系統(tǒng)。其中，左海馬下托體積對(duì)MMSE量表評(píng)分影響最大。
[關(guān)鍵詞]阿爾茨海默�。惠p度認(rèn)知障礙；結(jié)構(gòu)性磁共振；簡(jiǎn)易精神狀態(tài)評(píng)價(jià)量表；配對(duì)比較分析；多元線性回歸分析
[中圖分類號(hào)] R749.1+6 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2017)03(b)-0009-06
[Abstract]Objective To investigate the characteristics of structural magnetic resonance imaging (sMRI) of mild cognitive impairment (MCI) and Alzheimer disease (AD) in different brain regions，and to find out the characteristic indexes so as to provide assistance for early diagnosis.Methods Altogether 543 patients whose number ranged from 4018 to 5210 in the Alzheimer Disease Neuroimaging Initiative (ADNI) database from August 2014 July 2015 were randomly selected as the object of this research and divided into four groups according to the ADNI database diagnostic standards：139 cases in normal cognitive function group (CN)，220 cases in early mild cognitive impairment group (EMCI)， 108 cases in later mild cognitive impairment group (LMCI) and 76 cases in AD group.Mini-Mental State Examination (MMSE ) and 272 sMRI data of all the subjects were acquired.And multiple statistics methods were used，including the single-factor variance analysis， multiple comparison，nonparametric test，paired comparison analysis and multiple linear regression analysis，to discover the characteristic index that can make prediction of disease.Results The analysis results showed that among 272 sMRI data，28 indexes of CN group，EMCI group，LMCI group and AD group had statistically significant difference，of which there were 22 indexes in the pairing locations of the left and right brain region.Through analysis of the left and right brain regions by using paired comparison，a more serious atrophy was seen in the left hemisphere.According to the multiple linear regression analysis of 28 sMRI data and MMSE，the lower volume of the left hippocampus played the biggest influence on the MMSE score.Conclusion With the development of MCI into AD，the degree of brain atrophy is gradually increasing，and the left hemisphere is more severe in the progression of disease，among which，the lower volume of the left hippocampal has the greatest influence on the MMSE score. (齊雪丹 許凡宇 范炤)
[關(guān)鍵詞]阿爾茨海默�。惠p度認(rèn)知障礙；結(jié)構(gòu)性磁共振；簡(jiǎn)易精神狀態(tài)評(píng)價(jià)量表；配對(duì)比較分析；多元線性回歸分析
[中圖分類號(hào)] R749.1+6 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2017)03(b)-0009-06
[Abstract]Objective To investigate the characteristics of structural magnetic resonance imaging (sMRI) of mild cognitive impairment (MCI) and Alzheimer disease (AD) in different brain regions，and to find out the characteristic indexes so as to provide assistance for early diagnosis.Methods Altogether 543 patients whose number ranged from 4018 to 5210 in the Alzheimer Disease Neuroimaging Initiative (ADNI) database from August 2014 July 2015 were randomly selected as the object of this research and divided into four groups according to the ADNI database diagnostic standards：139 cases in normal cognitive function group (CN)，220 cases in early mild cognitive impairment group (EMCI)， 108 cases in later mild cognitive impairment group (LMCI) and 76 cases in AD group.Mini-Mental State Examination (MMSE ) and 272 sMRI data of all the subjects were acquired.And multiple statistics methods were used，including the single-factor variance analysis， multiple comparison，nonparametric test，paired comparison analysis and multiple linear regression analysis，to discover the characteristic index that can make prediction of disease.Results The analysis results showed that among 272 sMRI data，28 indexes of CN group，EMCI group，LMCI group and AD group had statistically significant difference，of which there were 22 indexes in the pairing locations of the left and right brain region.Through analysis of the left and right brain regions by using paired comparison，a more serious atrophy was seen in the left hemisphere.According to the multiple linear regression analysis of 28 sMRI data and MMSE，the lower volume of the left hippocampus played the biggest influence on the MMSE score.Conclusion With the development of MCI into AD，the degree of brain atrophy is gradually increasing，and the left hemisphere is more severe in the progression of disease，among which，the lower volume of the left hippocampal has the greatest influence on the MMSE score. (齊雪丹 許凡宇 范炤)