胸苷合成酶表達(dá)在培美曲塞治療晚期卵巢癌患者效果評(píng)估中的意義(1)
[摘要]目的 探討胸苷酸合成酶(TS)表達(dá)在培美曲塞治療晚期復(fù)發(fā)卵巢癌患者效果評(píng)估中的意義。方法 回顧性分析2010年7月~2014年7月我院80例接受培美曲塞聯(lián)合奈達(dá)鉑化療的晚期復(fù)發(fā)卵巢癌患者,其中實(shí)驗(yàn)組為40例經(jīng)免疫組化檢測(cè)TS表達(dá)陰性的患者,對(duì)照組40例為未經(jīng)TS酶檢測(cè),分析療效。結(jié)果 實(shí)驗(yàn)組:完全緩解(CR)2例,部分緩解(PR) 21例,穩(wěn)定(SD) 8例,進(jìn)展(PD)9例,對(duì)照組:CR 1例,PR 13例,SD 7例,PD 19例。實(shí)驗(yàn)組的總有效率、疾病控制率和1年生存率分別為57.5%、77.5%、60.0%,對(duì)照組分別是35.0%、52.5%、37.5%,兩組差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 TS可能成為預(yù)測(cè)晚期卵巢癌患者對(duì)培美曲塞敏感性的指標(biāo),TS表達(dá)陰性卵巢癌患者可能從含培美曲塞的化療方案中獲益。
[關(guān)鍵詞]胸苷酸合成酶;培美曲塞;卵巢癌;奈達(dá)鉑
[中圖分類號(hào)] R737.31 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2017)03(b)-0075-03
[Abstract]Objective To evaluate the significance of the thymidylate synthase (TS) expression in therapeutic effect evaluation of Pemetrexed in patients with advanced ovarion cancer.Methods Eighty patients with advanced recurrent ovarian cancer from July 2010 to July 2014 treated in our hospital were analyzed retrospectively ......
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[關(guān)鍵詞]胸苷酸合成酶;培美曲塞;卵巢癌;奈達(dá)鉑
[中圖分類號(hào)] R737.31 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2017)03(b)-0075-03
[Abstract]Objective To evaluate the significance of the thymidylate synthase (TS) expression in therapeutic effect evaluation of Pemetrexed in patients with advanced ovarion cancer.Methods Eighty patients with advanced recurrent ovarian cancer from July 2010 to July 2014 treated in our hospital were analyzed retrospectively ......
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