早卵泡期長方案與拮抗劑方案治療卵巢儲備功能下降年輕患者的效果比較(1)
[摘要]目的 比較早卵泡期長方案與拮抗劑方案治療卵巢儲備功能下降(DOR)年輕患者的效果。方法 回顧性分析2016年1月～2017年6月我院收治的272例行體外受精/卵胞漿內(nèi)單精子注射(IVF/ICSI)治療的35歲以下DOR患者的臨床資料，按照促排卵方案的不同將其分為A組(112例)和B組(160例)。A組患者采用早卵泡期長方案，B組患者采用拮抗劑方案。比較兩組患者的促排卵效果和妊娠結(jié)局，促排卵效果指標(biāo)包括促性腺激素(Gn)使用總量、人絨毛膜促性腺激素(HCG)日黃體生成素(LH)、HCG日內(nèi)膜厚度、獲卵數(shù)、優(yōu)質(zhì)胚胎率及移植胚胎數(shù)，以臨床妊娠率、種植率、活產(chǎn)率為妊娠結(jié)局的評價(jià)標(biāo)準(zhǔn)。結(jié)果 A組患者的Gn使用總量多于B組，HCG日LH水平低于B組，HCG日內(nèi)膜厚度、獲卵數(shù)、種植率、臨床妊娠率及活產(chǎn)率均高于B組，差異有統(tǒng)計(jì)學(xué)意義(P<0.05)；兩組患者的優(yōu)質(zhì)胚胎率、移植胚胎數(shù)比較，差異無統(tǒng)計(jì)學(xué)意義(P>0.05)。結(jié)論 對于DOR的年輕患者，早卵泡期長方案的效果優(yōu)于拮抗劑方案，更適合作為超促排卵備選方案。
[關(guān)鍵詞]早卵泡期長方案；拮抗劑方案；卵巢儲備功能下降；超促排卵
[中圖分類號] R984 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-4721(2019)5(c)-0062-03
[Abstract] Objective To compare the effect of early follicular long-term regimen and antagonist regimen in the treatment of young patients with diminished ovarian reserve (DOR). Methods The clinical data of 272 cases of DOR patients under 35 years of age who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment from January 2016 to June 2017 in our hospital were retrospectively analyzed. According to the different ovulation induction regimens， the patients were divided into group A (112 cases) and group B (160 cases). The patients in the group A received early follicular long-term regimen， and the patients in the group B received antagonist regimen. The ovulation induction effect and pregnancy outcomes were compared between the two groups. The ovulation induction indicators included gonadotrophin (Gn) total use， luteinizing hormone (LH) in human chorionic gonadotropin (HCG) day， HCG endometrial thickness， number of eggs obtained， high quality embryo rate and number of transplanted embryos. The clinical pregnancy rate， implantation rate， and live birth rate were used as the evaluation criteria for pregnancy outcome. Results The total use of Gn in group A was more than that in group B， the level of LH in HCG day was lower than that in group B， the HCG endometrial thickness， number of eggs obtained， planting rate， clinical pregnancy rate and live birth rate were higher than those in group B， and the differences were statistically significant (P<0.05). There were no significant differences in the quality of embryo rate and the number of transplanted embryos between the two groups (P>0.05). Conclusion For young patients with DOR， the effect of the early follicular long-term regimen is superior to that of the antagonist regimen and it is more suitable as an alternative regimen for ovarian hyper-stimulation.
[Key words] Early follicular long-term regimen； Antagonist regimen； Diminished ovarian reserve； Ovarian hyper-stimulation, 百拇醫(yī)藥(郭巖文 鄭娟 蔡嘉力)
[關(guān)鍵詞]早卵泡期長方案；拮抗劑方案；卵巢儲備功能下降；超促排卵
[中圖分類號] R984 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-4721(2019)5(c)-0062-03
[Abstract] Objective To compare the effect of early follicular long-term regimen and antagonist regimen in the treatment of young patients with diminished ovarian reserve (DOR). Methods The clinical data of 272 cases of DOR patients under 35 years of age who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment from January 2016 to June 2017 in our hospital were retrospectively analyzed. According to the different ovulation induction regimens， the patients were divided into group A (112 cases) and group B (160 cases). The patients in the group A received early follicular long-term regimen， and the patients in the group B received antagonist regimen. The ovulation induction effect and pregnancy outcomes were compared between the two groups. The ovulation induction indicators included gonadotrophin (Gn) total use， luteinizing hormone (LH) in human chorionic gonadotropin (HCG) day， HCG endometrial thickness， number of eggs obtained， high quality embryo rate and number of transplanted embryos. The clinical pregnancy rate， implantation rate， and live birth rate were used as the evaluation criteria for pregnancy outcome. Results The total use of Gn in group A was more than that in group B， the level of LH in HCG day was lower than that in group B， the HCG endometrial thickness， number of eggs obtained， planting rate， clinical pregnancy rate and live birth rate were higher than those in group B， and the differences were statistically significant (P<0.05). There were no significant differences in the quality of embryo rate and the number of transplanted embryos between the two groups (P>0.05). Conclusion For young patients with DOR， the effect of the early follicular long-term regimen is superior to that of the antagonist regimen and it is more suitable as an alternative regimen for ovarian hyper-stimulation.
[Key words] Early follicular long-term regimen； Antagonist regimen； Diminished ovarian reserve； Ovarian hyper-stimulation, 百拇醫(yī)藥(郭巖文 鄭娟 蔡嘉力)