非甾體抗炎藥在中醫(yī)骨傷科中運(yùn)用的合理性研究(1)
[摘要]目的 分析非甾體抗炎藥(NSAIDs)在我院中醫(yī)骨傷科中應(yīng)用的合理性。方法 回顧性分析2018年10月～2019年6月我院中醫(yī)骨傷科門診患者300例、住院患者200例，對(duì)NSAIDs使用情況進(jìn)行統(tǒng)計(jì)分析。結(jié)果 骨關(guān)節(jié)炎(33.60%)、頸肩腰腿痛(27.40%)、骨折(31.40%)是患者服用NSAIDs的主要原因;萘普生鈉注射液、醋氯芬酸鈉片、洛索洛芬鈉片、雙氯芬酸鈉緩釋片是NSAIDs中消耗金額的前4位;萘普生鈉注射液、醋氯芬酸鈉片、洛索洛芬鈉片、雙氯芬酸鈉緩釋片是用藥頻率DDs前四位;消化不良、轉(zhuǎn)氨酶升高、上腹疼痛、腹瀉等消化系統(tǒng)反應(yīng)是NSAIDs的最常見的不良反應(yīng)。結(jié)論 我院中醫(yī)骨傷科NSAIDs的臨床應(yīng)用較為合理，基本符合規(guī)定，應(yīng)對(duì)現(xiàn)有NSAIDs加強(qiáng)不良反應(yīng)監(jiān)測(cè)。
[關(guān)鍵詞]非甾體抗炎藥;中醫(yī)骨傷科;消耗金額;用藥頻度
[中圖分類號(hào)] R969 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2019)10(a)-0114-03
[Abstract] Objective To analyze the rationality of non-steroidal anti-inflammatory drugs (NSAIDs) in orthopedic department of traditional Chinese medicine in our hospital. Methods All retrospectivelly 300 cases of outpatients and 200 cases of inpatients and who were treated in our hospital from October 2018 to June 2019 were retrospectively analyzed， and the use of NSAIDs were counted and analyzed. Results The Osteoarthritis (33.60%)， neck， shoulder， waist and leg pain (27.40%) and fracture (31.40%) were the main reasons for taking NSAIDs. The Naproxen Sodium Injection， Sodium Acetate Tablets， Losoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were the top four consumption amount in NSAIDs; Naproxen Sodium Injection， Sodium Acetate， Loxoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were top four DDs in drug frequency. The dyspepsia， elevated transaminase， upper abdominal pain， diarrhea and other digestive system reactions were the most common adverse reaction of NSAIDs. Conclusion The clinical application of NSAIDs in our hospital are reasonable， it is basically in line with the regulations， thus the adverse reaction monitoring should be strengthened for existing NSAIDs.
[Key words] Non-steroidal anti-inflammatory drugs; Department of orthopedics in traclitional Chinese medicine; Consumption amount; Frequency of medication
非甾體抗炎藥(NSAIDs)是急、慢性風(fēng)濕性疾病的非類固醇一線治療藥物，具抗炎、鎮(zhèn)痛和解熱等作用，主要用于炎癥免疫性疾病的對(duì)癥治療，且無成癮性和依賴性，是臨床醫(yī)師特別是骨科醫(yī)師應(yīng)用較多的藥物之一[1-2]。中醫(yī)骨傷科是研究防治人體皮、肉、筋、骨損傷與疾患的一門科學(xué)，是祖國醫(yī)學(xué)重要的組成部分。因NSAIDs臨床效果顯著，其在中醫(yī)骨傷科臨床中的應(yīng)用最常見、最基礎(chǔ)，但其長(zhǎng)期使用或不規(guī)范使用，可導(dǎo)致上消化道出血、肝腎毒性、藥物過敏等不良反應(yīng)，危及患者生命[3-4]。本研究通過分析NSAIDs在本院中醫(yī)骨傷科的使用情況，分析NSAIDs應(yīng)用的有效性、安全性、合理性，從而用于指導(dǎo)和規(guī)范NSAIDs的使用，盡量減少此類藥物不良反應(yīng)，提高臨床用藥的安全性和有效性。
1資料與方法
1.1一般資料
本研究經(jīng)醫(yī)院醫(yī)學(xué)倫理委員會(huì)審核批準(zhǔn)，回顧性分析2018年10月～2019年6月我院中醫(yī)骨傷科門診患者300例、住院患者200例。
1.2方法
將信息錄入Excel表中，建立數(shù)據(jù)庫，并采用WHO建議的限定日劑量(DDD)作為藥物利用研究分析的測(cè)量單位，各種藥品的DDD值參考《新編藥物學(xué)》(17版)[5]并結(jié)合藥品說明書和臨床實(shí)際用藥情況確定。
1.3觀察指標(biāo), http://www.www.srpcoatings.com(江志勇 許楚宏 陳海燕 莊鵬)
[關(guān)鍵詞]非甾體抗炎藥;中醫(yī)骨傷科;消耗金額;用藥頻度
[中圖分類號(hào)] R969 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2019)10(a)-0114-03
[Abstract] Objective To analyze the rationality of non-steroidal anti-inflammatory drugs (NSAIDs) in orthopedic department of traditional Chinese medicine in our hospital. Methods All retrospectivelly 300 cases of outpatients and 200 cases of inpatients and who were treated in our hospital from October 2018 to June 2019 were retrospectively analyzed， and the use of NSAIDs were counted and analyzed. Results The Osteoarthritis (33.60%)， neck， shoulder， waist and leg pain (27.40%) and fracture (31.40%) were the main reasons for taking NSAIDs. The Naproxen Sodium Injection， Sodium Acetate Tablets， Losoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were the top four consumption amount in NSAIDs; Naproxen Sodium Injection， Sodium Acetate， Loxoprofen Sodium Tablets， Diclofenac Sodium Sustained-Release Tablets were top four DDs in drug frequency. The dyspepsia， elevated transaminase， upper abdominal pain， diarrhea and other digestive system reactions were the most common adverse reaction of NSAIDs. Conclusion The clinical application of NSAIDs in our hospital are reasonable， it is basically in line with the regulations， thus the adverse reaction monitoring should be strengthened for existing NSAIDs.
[Key words] Non-steroidal anti-inflammatory drugs; Department of orthopedics in traclitional Chinese medicine; Consumption amount; Frequency of medication
非甾體抗炎藥(NSAIDs)是急、慢性風(fēng)濕性疾病的非類固醇一線治療藥物，具抗炎、鎮(zhèn)痛和解熱等作用，主要用于炎癥免疫性疾病的對(duì)癥治療，且無成癮性和依賴性，是臨床醫(yī)師特別是骨科醫(yī)師應(yīng)用較多的藥物之一[1-2]。中醫(yī)骨傷科是研究防治人體皮、肉、筋、骨損傷與疾患的一門科學(xué)，是祖國醫(yī)學(xué)重要的組成部分。因NSAIDs臨床效果顯著，其在中醫(yī)骨傷科臨床中的應(yīng)用最常見、最基礎(chǔ)，但其長(zhǎng)期使用或不規(guī)范使用，可導(dǎo)致上消化道出血、肝腎毒性、藥物過敏等不良反應(yīng)，危及患者生命[3-4]。本研究通過分析NSAIDs在本院中醫(yī)骨傷科的使用情況，分析NSAIDs應(yīng)用的有效性、安全性、合理性，從而用于指導(dǎo)和規(guī)范NSAIDs的使用，盡量減少此類藥物不良反應(yīng)，提高臨床用藥的安全性和有效性。
1資料與方法
1.1一般資料
本研究經(jīng)醫(yī)院醫(yī)學(xué)倫理委員會(huì)審核批準(zhǔn)，回顧性分析2018年10月～2019年6月我院中醫(yī)骨傷科門診患者300例、住院患者200例。
1.2方法
將信息錄入Excel表中，建立數(shù)據(jù)庫，并采用WHO建議的限定日劑量(DDD)作為藥物利用研究分析的測(cè)量單位，各種藥品的DDD值參考《新編藥物學(xué)》(17版)[5]并結(jié)合藥品說明書和臨床實(shí)際用藥情況確定。
1.3觀察指標(biāo), http://www.www.srpcoatings.com(江志勇 許楚宏 陳海燕 莊鵬)