同型半胱氨酸、葉酸與維生素B12水平的相關(guān)性分析及不良妊娠結(jié)局的危險(xiǎn)因素考察(1)
[摘要]目的 探討同型半胱氨酸、葉酸與維生素B12水平的相關(guān)性及不良妊娠結(jié)局的危險(xiǎn)因素。方法 選擇2017年6月～2018年6月我院收治的不良妊娠結(jié)局孕婦50例作為研究組;另選擇同時(shí)間段我院收治的無不良妊娠結(jié)局孕婦50例作為對(duì)照組。觀察比較兩組的血清檢測(cè)結(jié)果，分析同型半胱氨酸與葉酸、維生素B12水平的相關(guān)性，并采用非條件Logistic多元逐步回歸分析不良妊娠相關(guān)危險(xiǎn)因素。結(jié)果 研究組的同型半胱氨酸為(11.20±2.85)μmol/L，高于對(duì)照組的(9.35±1.02)μmol/L，差異有統(tǒng)計(jì)學(xué)意義(P<0.05);研究組葉酸為(6.10±1.55)ng/ml，低于對(duì)照組的(6.95±1.68)ng/ml，差異有統(tǒng)計(jì)學(xué)意義(P<0.05);研究組維生素B12為(78.30±28.75)pg/ml，低于對(duì)照組的(98.35±45.50)pg/ml，差異有統(tǒng)計(jì)學(xué)意義(P<0.05);經(jīng)Pearson相關(guān)性分析結(jié)果可知，血清同型半胱氨酸水平與葉酸表現(xiàn)為負(fù)相關(guān)關(guān)系(r=-0.088，P=0.000);血清同型半胱氨酸水平與維生素B12水平表現(xiàn)為負(fù)相關(guān)關(guān)系(r=-0.109，P=0.001);非條件Logistic多元逐步回歸分析結(jié)果提示，同型半胱氨酸升高、維生素B12降低、葉酸降低均屬于不良妊娠的危險(xiǎn)因素(β=0.541，OR=1.708，95%CI=0.039～1.895，P<0.05;β=0.003，OR=1.001，95%CI=0.001～1.109，P<0.05;β=0.004，OR=1.002，95%CI=0.001～1.010，P<0.05)。結(jié)論 不良妊娠結(jié)局的相關(guān)危險(xiǎn)因素包括同型半胱氨酸升高、維生素B12水平降低、葉酸降低等，因此，臨床結(jié)合孕婦自身情況，應(yīng)加強(qiáng)同型半胱氨酸監(jiān)測(cè)，加強(qiáng)維生素B12、葉酸水平監(jiān)測(cè)，以有效預(yù)防發(fā)生不良妊娠結(jié)局。
[關(guān)鍵詞]同型半胱氨酸;葉酸;維生素B12水平;不良妊娠結(jié)局;相關(guān)性
[中圖分類號(hào)] R581.2 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2020)1(c)-0165-03
[Abstract] Objective To investigate the correlation between homocysteine， folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome. Methods A total of 50 pregnant women with adverse pregnancy outcome from June 2017 to June 2018 were selected as the study group， and 50 pregnant women with no adverse pregnancy outcome in the same time period were selected as the control group. The results of serum test were observed and compared， and the correlation between homocysteine and folic acid and vitamin B12 levels was analyzed， and the risk factors related to adverse pregnancy were analyzed by unconditional Logistic multiple stepwise regression analysis. Results The homocysteine in the study group was (11.20±2.85) μmol/L， which was higher than that in the control group (9.35±1.02) μmol/L， and the difference was statistically significant (P<0.05). The folic acid index in the study group was (6.10±1.55) ng/ml， lower than that in the control group (6.95±1.68) ng/ml， and the difference was statistically significant (P<0.05). The vitamin B12 index in the study group was (78.30±28.75) pg/ml， which was lower than that in the control group (98.35 ±45.50) pg/ml， and the difference was statistically significant (P<0.05). The results of Pearson correlation analysis showed that there was a negative correlation between serum homocysteine level and folic acid (r=-0.088， P=0.000). The serum homocysteine level was negatively correlated with the level of vitamin B12 (r=-0.109， P=0.001). Non-conditional Logistic multivariate regression analysis showed that the increase of homocysteine， the decrease of vitamin B12 and the decrease of folic acid were all risk factors of adverse pregnancy (β=0.541， OR=1.708， 95%CI=0.039-1.895， P<0.05; β=0.003， OR=1.001， 95%CI=0.001-1.109， P<0.05; β=0.004， OR=1.002， 95%CI=0.001-1.010， P<0.05). Conclusion The related risk factors of adverse pregnancy outcome include the increase of homocysteine， the decrease of vitamin B12 level and the decrease of folic acid. Therefore， combined with the situation of pregnant women， the monitoring of homocysteinemia， vitamin B12 and folic acid levels should be strengthen in order to effectively prevent the adverse pregnancy outcome., http://www.www.srpcoatings.com(李朝輝 胡雅 區(qū)敏怡)
[關(guān)鍵詞]同型半胱氨酸;葉酸;維生素B12水平;不良妊娠結(jié)局;相關(guān)性
[中圖分類號(hào)] R581.2 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2020)1(c)-0165-03
[Abstract] Objective To investigate the correlation between homocysteine， folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome. Methods A total of 50 pregnant women with adverse pregnancy outcome from June 2017 to June 2018 were selected as the study group， and 50 pregnant women with no adverse pregnancy outcome in the same time period were selected as the control group. The results of serum test were observed and compared， and the correlation between homocysteine and folic acid and vitamin B12 levels was analyzed， and the risk factors related to adverse pregnancy were analyzed by unconditional Logistic multiple stepwise regression analysis. Results The homocysteine in the study group was (11.20±2.85) μmol/L， which was higher than that in the control group (9.35±1.02) μmol/L， and the difference was statistically significant (P<0.05). The folic acid index in the study group was (6.10±1.55) ng/ml， lower than that in the control group (6.95±1.68) ng/ml， and the difference was statistically significant (P<0.05). The vitamin B12 index in the study group was (78.30±28.75) pg/ml， which was lower than that in the control group (98.35 ±45.50) pg/ml， and the difference was statistically significant (P<0.05). The results of Pearson correlation analysis showed that there was a negative correlation between serum homocysteine level and folic acid (r=-0.088， P=0.000). The serum homocysteine level was negatively correlated with the level of vitamin B12 (r=-0.109， P=0.001). Non-conditional Logistic multivariate regression analysis showed that the increase of homocysteine， the decrease of vitamin B12 and the decrease of folic acid were all risk factors of adverse pregnancy (β=0.541， OR=1.708， 95%CI=0.039-1.895， P<0.05; β=0.003， OR=1.001， 95%CI=0.001-1.109， P<0.05; β=0.004， OR=1.002， 95%CI=0.001-1.010， P<0.05). Conclusion The related risk factors of adverse pregnancy outcome include the increase of homocysteine， the decrease of vitamin B12 level and the decrease of folic acid. Therefore， combined with the situation of pregnant women， the monitoring of homocysteinemia， vitamin B12 and folic acid levels should be strengthen in order to effectively prevent the adverse pregnancy outcome., http://www.www.srpcoatings.com(李朝輝 胡雅 區(qū)敏怡)
參見：首頁 > 保健版 > 家庭用藥 > 維生素